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. 2022 Jun 21;13:890073. doi: 10.3389/fimmu.2022.890073

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Copyright © 2022 Wang, Min, Lai, Csomos, Wang, Liu, Meng, Sun, Hou, Ying, Zhou, Sun, Hui, Ujhazi, Gordon, Buchbinder, Schuetz, Butte, Walter, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cell subset distribution in the peripheral blood of APDS patients. (A) Gating strategy for the analysis of different B cell subsets. (B) Percentages of naïve B (CD19⁺IgD⁺CD27^-), MZB (CD19⁺IgD⁺CD27⁺) and B-1 B (CD20⁺CD27⁺CD43⁺) cells in healthy controls (HC) and the patients (APDS). (C) Proportions of IgG⁺ (class-switched) B, total memory B (CD19⁺IgD^-CD27⁺), and IgG⁺ and IgM⁺ memory B cells among the total memory B cells in HC and the patients. (D) Proportions of pre-plasmablast (pre-PB, CD38^hiCD27^hi), plasmablast (PB, CD20^-CD38^hi) and double negative B (DNB, CD19⁺IgD^-CD27^-) cells in HC and the patients. Grey column, HC (n=4); Open column, patient (n=5). *p < 0.05; ***p < 0.001 (unpaired t-test). Bars indicate mean ± SD.