Table 2.
Lymphocyte subpopulations in APDS patients.
| P # | CD19 | Transitional B | Naive B | Memory B | Plasmablsts | CD3 | CD4 | CD4 Naive | CD4 CM | CD4 EM | CD8 | CD8 Naive | CD8 CM | CD8 EM | CD8 TEMRA | DNT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | 5.9↓ | 50.8↑ | 71.9 | 10.7 | 8.5↑ | 47.5↓ | 52.4↑ | 10.3↓ | 48.7 | 41.0↑ | 41.1↑ | 17.0↓ | 32.7↑ | 28.1↑ | 22.1 | 0.72 |
| P2 | 2.5↓ | 3.9↓ | 5.7↓ | 31.3↑ | 23.9↑ | 73.9 | 28.7 | 9.3↓ | 28.7↓ | 34.1↑ | 57.7↑ | 20.2↓ | 33.3 | 34.0↑ | 12.5 | 0.29↓ |
| P4 | 2.6↓ | 18.8↑ | 48.5↓ | 1.3↓ | 20.0↑ | 27.3↓ | 23.1 | 4.2↓ | 13.0↓ | 67.3↑ | 61.2↑ | 4.1↓ | 9.6↓ | 32.4↑ | 53.9↑ | 0.08↓ |
| P5 | 20.8↑ | 42.4↑ | 66.5 | 4.6↓ | 19.0↑ | 65.9 | 32.1 | 14.6↓ | 63.9↑ | 21.4↑ | 45.9↑ | 5.5↓ | 23.2 | 31.5↑ | 39.8↑ | 0.45 |
| P6 | 6.6↓ | 73.7↑ | 63.4↓ | 15.0↑ | 15.5↑ | 75.6↑ | 21.6↓ | 3.1↓ | 84.5↑ | 12.4↑ | 72.6↑ | 20.4↓ | 57.7↑ | 12.5 | 9.4 | 0.63 |
| P7 | 5.1↓ | 72.9↑ | 31.4↓ | 13.3 | 17.7↑ | 49.0↓ | 46.6↑ | 16.6↓ | 72.9↑ | 10.4↑ | 46.7↑ | 15.1↓ | 47.1↑ | 20.8↑ | 17.0 | 0.41 |
| P8 | 28.7 | 72.6↑ | 0.1↓ | 2.3 | 1.2 | 54.5 | 51.8 | 52.1↓ | 36.0↑ | 11.0↑ | 42.8↑ | 20.8↓ | 30.3↑ | 30.7↑ | 18.3↑ | 0.47 |
| P9 | 5.8↓ | 23.4↑ | 40.5↓ | 6.1↓ | 9.6 | 65.3 | 36.1 | 11.3↓ | 53.5↑ | 35.0↑ | 45.4↑ | 6.0↓ | 19.7 | 35.2↑ | 39.1↑ | 0.43 |
| P10 | 16.9 | 75.4↑ | 48.7 | 6.8↓ | 6.2 | 56.0↓ | 44.0↑ | 17.1↓ | 77.1↑ | 5.4 | 51.1↑ | 14.5↓ | 60.0↑ | 14.7↑ | 10.8 | 0.56 |
| P11 | 3.4↓ | 1.8↓ | 42.9↓ | 10.1 | 22.3↑ | 64.6 | 34.9 | 5.9↓ | 43.9 | 50.1↑ | 58.4↑ | 7.4↓ | 31.9 | 33.0↑ | 27.7↑ | 0.63↓ |
| P12 | 3.9↓ | 66.1↑ | 77.8↑ | 3.3↓ | 9.6↑ | 87.7↑ | 14.0↓ | 18.4↓ | 71.8↑ | 8.6 | 82.1↑ | 10.9↓ | 16.2 | 31.9↑ | 40.9↑ | 0.16↓ |
| P13 | 2.0↓ | 53.7↑ | 29.8↓ | 7.8 | 10.6↑ | 66.8 | 18.2↓ | 15.1↓ | 72.4↑ | 12.5↑ | 74.9↑ | 10.6↓ | 64.8↑ | 17.9↑ | 6.7 | 0.95 |
| P14 | 3.3↓ | 71.3↑ | 77.4↑ | 4.3↓ | 9.1↑ | 83.8↑ | 21.3↓ | 12.2↓ | 46.7↑ | 35.3↑ | 61.8↑ | 5.2↓ | 23.7 | 42.7↑ | 28.4↑ | 0.51 |
| P15 | 9.2↓ | 46.5↑ | 78.7↑ | 12.0 | 17.1↑ | 73.6 | 19.2↓ | 25.2↓ | 63.0↑ | 11.5↑ | 75.5↑ | 9.3↓ | 9.7↓ | 39.4↑ | 41.7↑ | 0.76 |
| P16 | 6.8↓ | 52.5↑ | 79.2↑ | 3.5↓ | 5.4 | 50.2↓ | 30.5 | 19.1↓ | 34.0 | 43.2↑ | 42.4↑ | 14.3↓ | 35.5↑ | 20.8↑ | 29.4↑ | 0.27 |
| P19 | 11.0 | 28.0↑ | 82.0↑ | 12.0 | 3.0 | 69.0 | 30.0 | 30.0 | n.a. | n.a. | 38.1↑ | 15.0↓ | n.a. | n.a. | n.a. | n.a. |
| P20 | 13.0 | 5.0 | 64.0 | 27.0↑ | 6.2 | 77.0↑ | 41.0 | 32.0 | 52.0↑ | 10.0↑ | 40.0↑ | 38.0↓ | 57.0↑ | 5.0 | 0↓ | n.a. |
| P21 | 9.0↓ | 30.0↑ | 68.0 | 22.0 | 5.2 | 70.0 | 55.0↑ | 85.0↑ | 10.0↓ | 2.0↓ | 39.0↑ | 50.0 | 42.0↑ | 3.0 | 1.0↓ | n.a. |
| P22 | 12.5 | 16.0↑ | 49.0 | 17.0 | 21.4↑ | 62.0 | 46.0↑ | 12.0↓ | 71.0↑ | 16.0 | 46.0↑ | 6.0↓ | 76.0↑ | 18.0↑ | 1.0↓ | n.a. |
| P23 | 51.0↑ | 2.2 | 33.4↓ | 7.4↓ | n.a. | 40.0↓ | 69.4↑ | 34.0↓ | 53.0↑ | 11.0 | 27.8 | 74.0↑ | 12.0↓ | 13.0 | 8.0 | n.a. |
| P24 | 25.0↑ | 8.3 | 19.1↓ | 5.0↓ | n.a. | 59.0 | 29.4 | 9.0↓ | 51.0↑ | 39.0↑ | 56.4↑ | 58.0 | 11.0↓ | 29.0↑ | 29.0↑ | n.a. |
Lymphocyte subpopulation was not analyzed for patients 3, 17, and 18.
DNT, TCRαβ+ CD4 and CD8 double-negative T cell.
n.a., not available. ↓ Below the reference range. ↑ Above the reference range.