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. 2022 Jun 21;12:881252. doi: 10.3389/fonc.2022.881252

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Copyright © 2022 Su, Yu, Mao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Working model of the role of HIF-1α/ERRα in cancer cell metabolism. Cancer cells can adapt to low oxygen conditions through the PI3K/AKT/mTOR and AMPK signaling pathways, which regulate metabolic reprogramming. ERRα interacts with HIF-1α, enhancing the transcriptional activity of HIF-1α and promoting the remodeling of glucose and lipid metabolism (formation of lipid droplets) in cancer cells. ERRα also enhances glutamine metabolism and lipid de novo synthesis, promoting metabolic adaptation in cancer cells. Together, these activities stimulate tumor proliferation, metastasis, and angiogenesis. Images were made in BioRender (Biorender.com).