Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Working model of the role of HIF-1α/ERRα in pyroptosis resistance. HIF-1 α is a component of the molecular mechanism of pyroptosis mediated by NLRP3 inflammatory bodies, which can recruit immune cells to mediate the immune response. HIF-1α/ERRα interaction promotes the adaptation of tumor cells to hypoxia and promotes cancer cell resistance to pyroptosis. These activities stimulate tumor proliferation, metastasis, and drug resistance. Images were made in BioRender (Biorender.com).
