Table 1.
Studies on HIF-1α regulation of glucose and lipid metabolism and promotion of gynecological malignant tumor progression.
| Author | Cancer type | Main finding |
|---|---|---|
| Giatromanolaki et al. (57) | EC | HIF-1α is highly expressed in proliferating endometrium nuclei, which is related to tumor invasion. |
| Wincewicz et al. (58) | EC | Activators of transcription (STAT3) mediates the signal transduction of HIF-1α to stimulate tumor growth and maintain the invasive ability of EC cells. |
| Seeber et al. (59) | EC | HIF-1α expression is often accompanied by the activation of its downstream factor GLUT-1, which makes cancer cells survive in the hypoxic environment, and is related to aggressive tumor behavior. |
| Yeramian et al. (60) | EC | HIF-1α regulates the transcriptional activity of NF- κB and the accumulation of nuclear RelA in Ishikawa cells, and mediates the survival of EC cells under hypoxia. |
| Ai et al. (61) | Ovarian cancer | Knockout of HIF-1α can redirect aerobic glycolysis in drug-resistant ovarian cancer cells to mitochondrial OXPHOS, resulting in cell death through the production of ROS, thus improving the response of cisplatin-resistant ovarian cancer cells to cisplatin. |
| Triantafyllou et al. (62) | Cervical cancer | In tumor hypoxia microenvironments, HIF-1α promotes fatty acid uptake by inducing fatty acid binding protein and PPARγ, inducing phosphatidic acid phosphatase LIPIN1 production, regulating fatty acid synthesis, and promoting lipid storage by regulating the expression of acylglycerol-3-phosphate acyltransferase 2 (AGPAT2) and LIPIN1. This results in chemotherapy resistance in tumor cells. |
| Gong et al. (63) | EC | AGR2, a member of the endoplasmic reticulum resident protein disulfide isomerase family, induces lactate dehydrogenase A (LDHA), phosphoglycerate kinase 1 (PGK1), kallikrein 2(HK2), and enolase 1-α(ENO1) expression, glucose uptake, and lactic acid production as well as promotes the progress of EC through the MUC1/HIF-1α pathway. |
| Gao et al. (64) | Ovarian cancer | As it is a key regulator of glucose metabolism in ovarian cancer cells, activation of the PI3K/AKT/HIF-1α signaling pathway plays an important carcinogenic role in promoting the growth and metastasis of ovarian cancer. |