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. 2022 Jul 4;7:75. doi: 10.1038/s41541-022-00503-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The central region of the genome contains a conserved series of genes needed for viral replication. The two flanking regions code for several proteins that help determine virulence. When used as a viral vector in vaccinations, the D1–13 transcription units (indicated between the dotted lines) are replaced by the transgene of choice.