Table 1.
Clinical and imaging characteristics in high vs. low VEGF groups and wild-type vs. mutant p53 groups.
| Parameter | High VEGF (N = 49) | Low VEGF (N = 31) | p-value | Wild-type p53 (N = 68) | Mutant p53 (N = 12) | p-value |
|---|---|---|---|---|---|---|
| Clinical characteristics | ||||||
| Age | 33.3 ± 13.3 | 32.2 ± 10.7 | 0.701 | 32.6 ± 12.0 | 34.3 ± 14.0 | 0.694 |
| VAS score | 5.9 ± 1.6 | 6.4 ± 1.4 | 0.126 | 6.1 ± 1.6 | 6.1 ± 1.2 | 0.962 |
| SINS score | 12.2 ± 2.0 | 9.9 ± 2.0 | <0.001* | 11.0 ± 2.2 | 12.8 ± 2.4 | 0.030* |
| Symptom duration (months) | 12.9 ± 6.8 | 12.6 ± 4.1 | 0.769 | 12.0 ± 4.9 | 17.4 ± 8.4 | 0.05 |
| Intraoperative bleeding vol (ml) | 1125 ± 565 | 574 ± 303 | <0.001* | 843 ± 452 | 1,300 ± 854 | 0.095 |
| Spinal stability | <0.001* | 0.013* | ||||
| 0: Stable | 24 (49.0%) | 28 (90.3%) | 48 (70.6%) | 4 (33.3%) | ||
| 1: Unstable | 25 (51.0%) | 3 (9.7%) | 20 (29.4%) | 8 (66.7%) | ||
| Enneking stage | 0.910 | 0.017* | ||||
| 1 | 31 (63.3%) | 20 (64.5%) | 47 (69.1%) | 4 (33.3%) | ||
| 2 | 18 (36.7%) | 11 (35.5%) | 21 (30.9%) | 8 (66.7%) | ||
| Imaging characteristics | ||||||
| Lesion location | 0.242 | 0.642 | ||||
| Cervical | 18 (36.7%) | 8 (25.8%) | 22 (32.4%) | 4(33.3%) | ||
| Thoracic | 20 (40.8%) | 13 (41.9%) | 27 (39.7%) | 6 (50.0%) | ||
| Lumbar | 5 (10.2%) | 8 (25.8%) | 11 (16.2%) | 2 (16.7%) | ||
| Sacral | 6 (12.3%) | 2 (6.5%) | 8 (11.7%) | 0 (0.0%) | ||
| Position | 0.386 | 0.861 | ||||
| Vertebral body | 43 (87.8%) | 25 (80.6%) | 58 (85.3%) | 10 (83.3%) | ||
| Vertebral arch | 6 (12.2%) | 6 (19.4%) | 10 (14.7%) | 2 (16.7%) | ||
| Vertebral compression | 0.981 | 0.741 | ||||
| 0% | 15 (30.6%) | 10 (32.3%) | 22 (32.4%) | 3 (25.0%) | ||
| ≤50% | 20 (40.8%) | 12 (38.7%) | 26 (38.2%) | 6 (50.0%) | ||
| >50% | 14 (28.6%) | 9 (29.0%) | 20 (29.4%) | 3 (25.0%) | ||
| Lesion boundary | 0.636 | 0.044* | ||||
| Clear | 47 (95.9%) | 29 (93.5%) | 66 (97.1%) | 10 (83.3%) | ||
| Unclear | 2 (4.1%) | 2 (6.5%) | 2 (2.9%) | 2 (16.7%) | ||
| Residual bone crest | 0.779 | 0.443 | ||||
| Yes | 19 (38.8%) | 13 (41.9%) | 26 (38.2%) | 6 (50.0%) | ||
| No | 30 (61.2%) | 18 (58.1%) | 42 (61.8%) | 6 (50.0%) | ||
| “Soap bubble-like” sign | 0.815 | 0.292 | ||||
| Yes | 45 (91.8%) | 28 (90.3%) | 63 (92.6%) | 10 (83.3%) | ||
| No | 4 (8.2%) | 3 (9.7%) | 5 (7.4%) | 2 (16.7%) | ||
| CT Hounsfield value | 48.1 ± 9.5 | 47.5 ± 10.0 | 0.795 | 47.8 ± 9.9 | 48.2 ± 8.3 | 0.905 |
| Largest diameter | 4.9 ± 1.7 | 5.3 ± 2.1 | 0.310 | 5.1 ± 1.9 | 4.8 ± 1.1 | 0.428 |
*p-value <0.05; VAS, Visual Analog Scale; SINS, Spinal Instability Neoplastic Score.