Table 2. Intra- and inter-day precision and accuracy data for the duloxetine and thioctic acid assays in beagle dog plasma.

Concentrations		Duloxetine				Thioctic acid
		LLOQ (5 ng/mL)	LQC (15 ng/mL)	MQC (150 ng/mL)	HQC (640 ng/mL)	LLOQ (5 ng/mL)	LQC (15 ng/mL)	MQC (100 ng/mL)	HQC (800 ng/mL)
Accuracy (%)
	Batch 1	105.04	108.44	104.59	106.49	98.00	98.58	100.93	100.38
	Batch 2	100.96	99.15	98.61	101.83	101.83	107.45	100.79	100.94
	Batch 3	96.36	105.23	100.01	100.72	106.83	98.28	99.68	101.42
	Inter-batch	100.79	104.27	101.07	103.02	102.22	101.44	100.47	100.92
Precision (%CV)
	Batch 1	7.73	2.14	2.27	1.65	3.95	0.96	1.14	0.64
	Batch 2	4.89	2.66	1.58	2.46	1.89	3.21	1.98	0.82
	Batch 3	0.11	5.40	3.97	1.71	0.10	1.72	2.32	0.38
	Inter-batch	7.25	3.68	3.10	3.10	7.35	1.83	0.73	0.73

LLOQ, lower limit of quantification; LQC, low quality control; MQC, middle quality control; HQC, high quality control; CV, coefficient of variation.