Table 3. Matrix effects in beagle dog plasma (n = 6).

Number	Duloxetine		Thioctic acid
	LQC (15 ng/mL)	HQC (640 ng/mL)	LQC (15 ng/mL)	HQC (800 ng/mL)
1	34.13	1,221.76	0.015	0.892
2	28.53	1,196.35	0.016	0.900
3	27.82	1,180.54	0.016	0.907
4	27.84	1,224.56	0.017	0.914
5	29.47	1,179.33	0.016	0.912
6	28.27	1,217.51	0.016	0.883
%CV	8.26	1.72	4.15	1.34

All values are represented as peak area ratios.

LQC, low quality control; HQC, high quality control; CV, coefficient of variation.