Posterior probabilities for fractional anisotropy (FA) values in a) the corticospinal tract (CST), b) the corticopontine and corticorubral tracts, c) the corticostriatal pathway, and d) the proximal portion of the perforant pathway to be classified as ‘altered’ (, orange) or ‘not altered’ ( grey). The individual tract systems were analyzed independently and the respective threshold of the threshold-based staging method is shown as dashed blue line.