Table 2.

Association of individual SLC12A3 gene variants and estimated glomerular filtration rate (cohort 1).

SNP	Position	Role	Genotype	Frequency	Allele	MAF	HWE	r	P-value
rs16963397	chr16:56927441	Intron	C/C	55 (6.2%)	G:C	0.244	0.636	0.094	0.005
			C/G	320 (36.3%)
			G/G	507 (57.5%)
rs13334864	chr16:56929841	Intron	C/C	131 (14.9%)	T:C	0.406	<0.001	0.078	0.020
			C/T	325 (36.8%)
			T/T	426 (48.3%)
rs7187932	chr16:56931704	Intron	A/A	63 (7.1%)	G:A	0.245	0.073	0.083	0.014
			A/G	307 (34.8%)
			G/G	512 (58.0%)
rs12449275	chr16:56937855	Intron	A/A	35 (4.0%)	G:A	0.124	<0.001	0.044	0.188
			A/G	148 (16.8%)
			G/G	699 (79.3%)
rs12447287	chr16:56937998	Intron	C/C	43 (4.9%)	T:C	0.145	<0.001	0.054	0.109
			C/T	170 (19.3%)
			T/T	669 (75.9%)
rs1138429	chr16:56942921	Intron	A/A	626 (71.0%)	A:T	0.162	0.091	0.025	0.461
			A/T	226 (25.6%)
			T/T	30 (3.4%)

HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; r, correlation coefficient; SNP, single nucleotide polymorphisms.

Alleles shown are major:minor.