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. 2022 Jun 21;12:906778. doi: 10.3389/fonc.2022.906778

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Copyright © 2022 Lin, Zhang, Yu, Bi, Zhang, Yin, Zhao, Liang, Qu, Wang, Hu, Liu, Wang, Zhou, Wang, Tan, Liu, Shao, Cai, Tang and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The dynamic trend of clinical parameters of PLC patients from 2003 to 2020. (A) The proportions of HCC, HBV seropositivity, HCV seropositivity, and early BCLC stage in PLC. (B) The proportions of HBV seropositivity, HCV seropositivity, and early BCLC stage in HCC. (C) The dynamic trends of 1-year, 3-year, and 5-year survival rates. Linear trends were calculated by using Cochran-Armitage test. BCLC, Barcelona Clinic Liver Cancer; HBV, hepatitis B virus; HCV, hepatitis C virus; HCC, hepatocellular carcinoma.