Table 2.
Comparison of demographic and clinical characteristics in HCC patients with information on HBV infection.
| Variable | Total (n = 12,824) | Patients without HBV infection (n = 2,001) | Patients with HBV infection (n = 10,823) | P-value |
|---|---|---|---|---|
| Age (year) | ||||
| Medium (IQR) | 53 (46-61) | 60 (53-68) | 52 (45-60) | |
| <40 | 1,356 (10.6) | 103 (5.1) | 1,253 (11.6) | <0.001 |
| 40–59 | 7,639 (59.6) | 822 (41.1) | 6,817 (63.0) | |
| ≥60 | 3,829 (29.8) | 1,076 (53.8) | 2,753 (25.4) | |
| Gender | ||||
| Female | 1,718 (13.4) | 302 (15.1) | 1,416 (13.1) | 0.015 |
| Male | 11,106 (86.6) | 1,699 (84.9) | 9,407 (86.9) | |
| HCV | ||||
| Negative | 9,710 (96.9) | 1,480 (86.8) | 8,230 (98.9) | <0.001 |
| Positive | 315 (3.1) | 225 (13.2) | 90 (1.1) | |
| Cirrhosis | ||||
| No | 5,762 (50.7) | 1,052 (67.9) | 4,710 (48.0) | <0.001 |
| Yes | 5,610 (49.3) | 498 (32.1) | 5,112 (52.0) | |
| Ascites | ||||
| No | 10,488 (96.6) | 1,336 (95.5) | 9,152 (96.8) | 0.016 |
| Yes | 370 (3.4) | 63 (4.5) | 307 (3.2) | |
| BCLC stage | ||||
| 0 | 451 (3.7) | 47 (3.2) | 404 (4.2) | <0.001 |
| A | 4,670 (39.6) | 694 (47.7) | 3,976 (41.4) | |
| B | 4,018 (38.0) | 518 (35.6) | 3,500 (36.4) | |
| C | 1,926 (18.7) | 197 (13.5) | 1,729 (18.0) | |
| Tumor thrombus | ||||
| No | 6,812(65.0) | 875 (68.1) | 5,937 (64.5) | 0.011 |
| Yes | 3,670(35.0) | 409 (31.9) | 3,261 (35.5) | |
| Tumor nodule | ||||
| Single | 8,084 (80.1) | 987 (84.2) | 7,097 (79.6) | <0.001 |
| Multiple | 2,003 (19.9) | 185 (15.8) | 1,818 (20.4) | |
| Tumor diameter (cm) | ||||
| <3 | 1,644 (12.7) | 175 (10.6) | 1,298 (12.7) | 0.007 |
| ≥3 | 9,950 (87.3) | 1,469 (89.4) | 8,652 (87.3) | |
| Tumor capsule | ||||
| Yes | 7,129 (70.8) | 830 (70.6) | 6,299 (70.8) | 0.867 |
| No | 2,942 (29.2) | 346 (29.4) | 2,596 (29.2) | |
| AFP (ng/ml) | ||||
| <20 | 4,417 (37.6) | 800 (49.9) | 3,617 (35.6) | <0.001 |
| ≥20 | 7,334 (62.4) | 803 (50.1) | 6,531 (64.4) | |
| Total bilirubin (µmol/L) | ||||
| ≤23 | 9,483 (88.9) | 1,152 (88.5) | 8,331 (88.9) | 0.635 |
| >23 | 1,188 (11.1) | 150 (11.5) | 1,038 (11.1) | |
| Direct bilirubin (µmol/L) | ||||
| ≤8 | 8,444 (81.5) | 965 (81.4) | 7,479 (81.5) | 0.976 |
| >8 | 1,921 (18.5) | 220 (18.6) | 1,701 (18.5) | |
| Albumin (g/L) | ||||
| ≥40 | 6,555 (59.6) | 912 (62.8) | 5,643 (59.1) | 0.007 |
| <40 | 4,451 (40.4) | 541 (37.2) | 3,910 (40.9) | |
Data are shown in n (%).