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. 2022 Jun 21;13:739999. doi: 10.3389/fneur.2022.739999

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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Average 12-month outcomes for every 85 patients with asymptomatic carotid stenosis randomized to CEA in ACAS (35). Calculated from ACAS data regarding patients with 60–99% asymptomatic carotid stenosis (using “NASCET” criteria), the overall absolute annual ACAS stroke risk reduction from CEA and the 2.3% 30-day CEA rate of stroke or death in ACAS (35). There was a 5.9% reduction in any peri-operative stroke/death or later ipsilateral stroke in ACAS with CEA over 5 years using Kaplan Meier analysis (11.0% with medical intervention alone vs. 5.1% with CEA, or 1.18%/year risk reduction with CEA). Therefore, the number needed to treat by CEA to be ahead by 1 ipsilateral stroke over 12 months of study follow-up was 100/1.18 = 85. Derived from a figure originally published in Fast Facts, 2012 (©S. Karger AG, Basel) (40).