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. 2022 Jun 21;13:739999. doi: 10.3389/fneur.2022.739999

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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Average 12-month outcomes for every 31 symptomatic patients randomized to CEA in NASCET, ECST, and VACS. Calculated from pooled randomized trial data regarding symptomatic patients with 70–99% stenosis (using “NASCET criteria” and excluding near occlusion), the overall absolute stroke risk reduction with CEA and the overall 30-day CEA rate of stroke or death of 6.2% (4). There was a 16% reduction in any peri-operative stroke/death or later ipsilateral stroke with CEA over 5 years using Kaplan Meier analysis (~27.0% with medical intervention alone vs. 11.0% with CEA, or 3.2%/year risk reduction with CEA) (4). Therefore, the number needed to treat by CEA to be ahead by 1 ipsilateral stroke over 12 months of study follow-up was 100/3.2 = 31.25 (40). Derived from a figure originally published in Fast Facts, 2012, and now with a correction (©S. Karger AG, Basel) (40).