Table 2.

Peri-procedural rate of stroke or death with CAS compared to CEA in the largest randomized trials of patients with asymptomatic carotid stenosis.

Randomized trial	n	Follow-Up (years)	30-Day peri- procedural stroke/death rate (%)		CAS excess	P
			CAS	CEA	OR/HR, 95% CI
ACST-2 (68)∧	3,625	5 mean	3.5	2.6	OR 1.35 (0.91–2.03)*	0.12
ACT-1, 2016 (69)	1,453	0–5	2.9	1.7	OR 1.69 (0.70–4.10)*	0.24
CREST-1, 2010 (65)	1,181	2.5 median	2.5	1.4	HR 1.88 (0.79–4.42)	0.15
SPACE-2, 2016 (38)	400	1–5	2.5	2.0	OR 1.30 (0.34–4.90)*	0.70
SAPPHIRE, 2004 (70)	237	1	5.4	4.6	1.2 times higher (no raw data published to allow statistical calculations)	?

Individually each randomized trial was statistically underpowered to exclude a clinically significant difference in the rate of peri-procedural stroke or death with CEA and CAS.

^*OR calculated from published raw data.

^∧Analysis using intention to treat figures.