Table 1.
Patient characteristics of the dx cohort (n = 50)
| Patient no. | Patient age [months] | Treatment protocol | sex | Time to event (last follow-up) [months] | HOXA9 ΔCT Mean |
IRX1 ΔCT Mean |
EGR3 ΔCT Mean |
ICOSLG ΔCT Mean |
|---|---|---|---|---|---|---|---|---|
| 1 | 5.0 | Interfant-06 | F | (40.1) | 13.3592 | 6.1705 | 8.1850 | 7.6499 |
| 2 | 6.0 | / | F | / | 3.9204 | 7.7667 | 11.2758 | 8.0223 |
| 3 | 2.0 | Interfant-06 | F | (23.6) | 12.9546 | 7.1581 | 9.3618 | 7.1255 |
| 4 | 6.0 | Interfant-06 | M | (17.1) | 11.5783 | 7.9774 | 11.1637 | 7.8868 |
| 5 | 10.0 | / | M | / | 3.5974 | 8.3317 | 8.8214 | 6.0364 |
| 6 | 2.0 | Interfant-06 | M | (83.6) | 4.9698 | 9.5555 | 11.5618 | 6.8416 |
| 7 | 3.0 | Interfant-06 | F | (5.6) | 11.0093 | 5.1167 | 8.5196 | 5.6658 |
| 8 | 3.0 | Interfant-06 | F | (1.2) | 4.9163 | 6.4184 | 8.2271 | 4.8055 |
| 9 | 3.0 | Interfant-06 | M | (2.5) | 4.5976 | 9.0338 | 8.0114 | 9.8380 |
| 10 | 6.0 | Interfant-06 | F | 9.5 (10.7) | 5.0818 | 8.4812 | 12.3136 | 9.3984 |
| 11 | 0.1 | / | F | / | 8.6964 | 8.0250 | 11.2989 | 9.9469 |
| 12 | 1.0 | / | M | / | 12.3443 | 6.0576 | 11.6236 | 8.4245 |
| 13 | 12.0 | / | F | / | 2.2824 | 7.9734 | 9.1826 | 7.9894 |
| 14 | 4.0 | / | F | / | 11.4825 | 6.3166 | 11.4695 | 9.0590 |
| 15 | 2.0 | Interfant-06 | M | 6.0 (6.0) | 4.6973 | 5.9447 | 13.3440 | 8.7451 |
| 16 | 5.5 | Interfant-06 | M | 9.5 (15.0) | 6.2129 | 6.5399 | 9.5330 | 8.2498 |
| 17 | 1.5 | Interfant-06 | F | 10.0 (13.0) | 6.0703 | 4.9900 | 6.2132 | 4.0517 |
| 18 | 3.0 | Interfant-06 | F | 6.0 (11.5) | 2.0906 | 8.4791 | 9.4723 | 8.5023 |
| 19 | 2.0 | Interfant-06 | F | 10.5 (19) | 7.8537 | 3.1429 | 7.2056 | 5.2518 |
| 20 | 1.5 | Interfant-06 | M | 26.5 (41.0) | 4.4627 | 8.3685 | 11.2026 | 7.5564 |
| 21 | 6.5 | Interfant-06 | M | 24.0 (32.8) | 11.2673 | 5.3156 | 8.7817 | 8.6026 |
| 22 | 6.0 | Interfant-06 | F | 19.5 (23.5) | 11.5891 | 7.0636 | 10.0553 | 7.8697 |
| 23 | 12.0 | Interfant-06 | F | 32.0 (60.6) | 11.1226 | 4.2582 | 8.0600 | 7.3822 |
| 24 | 9.0 | Interfant-06 | M | (84.9) | 8.7665 | 2.2034 | 7.0569 | 5.8906 |
| 25 | 2.0 | Interfant-06 | F | (118.8) | 4.6017 | 7.1138 | 10.2925 | 7.1171 |
| 26 | 3.0 | Interfant-06 | M | 8.0 (108.5) | 13.0872 | 5.9083 | 8.7375 | 8.5604 |
| 27 | 5.5 | Interfant-06 | M | (9.0) | 5.9626 | 8.1536 | 9.1105 | 8.6464 |
| 28 | 5.0 | Interfant-06 | M | 17.0 (33.0) | 5.9922 | 4.8934 | 5.0456 | 3.8081 |
| 29 | 2.0 | Interfant-06 | F | 56.0 (58.6) | 5.3297 | 8.4461 | 9.3271 | 8.9127 |
| 30 | 1.5 | Interfant-06 | F | (146.1) | 5.8358 | 8.0518 | 9.8910 | 8.1978 |
| 31 | 8.3 | Interfant-06 | F | (109.3) | 2.2195 | 6.2132 | 6.5075 | 6.2880 |
| 32 | 8.2 | Interfant-06 | M | (95.9) | 1.7726 | 7.4956 | 7.2074 | 7.4143 |
| 33 | 10.7 | Interfant-06 | M | 8.8 (8.8) | 2.6953 | 3.0935 | 2.4138 | 4.9064 |
| 34 | 1.7 | Interfant-06 | F | (91.5) | 3.8579 | 7.1200 | 6.2540 | 7.6448 |
| 35 | 11.7 | Interfant-06 | F | (73.2) | 2.9311 | 7.9152 | 10.9273 | 7.2855 |
| 36 | 10.4 | Interfant-06 | F | (75.9) | 5.7541 | 8.8581 | 10.4144 | 9.1282 |
| 37 | 2.4 | Interfant-06 | F | (73.8) | 13.3331 | 6.1426 | 9.8438 | 9.0200 |
| 38 | 4.5 | Interfant-06 | M | 16.1 (63.5) | 4.6562 | 8.9152 | 11.4891 | 8.7484 |
| 39 | 1.1 | Interfant-06 | F | 3.3 (15.7) | 12.9071 | 6.3552 | 11.9464 | 9.3496 |
| 40 | 5.3 | Interfant-06 | M | (58.7) | 5.4284 | 8.4380 | 10.3705 | 8.3493 |
| 41 | 6.9 | Interfant-06 | F | (63.2) | 9.2472 | 8.5374 | 9.7053 | 6.0532 |
| 42 | 5.3 | Interfant-06 | M | (60.7) | 3.4737 | 7.4371 | 9.5640 | 7.1599 |
| 43 | 0.6 | Interfant-06 | F | 5.0 (11.9) | 7.9122 | 6.2711 | 8.6364 | 8.0174 |
| 44 | 1.5 | Interfant-06 | M | 17.3 (18.3) | 8.1333 | 8.0008 | 9.5745 | 7.1672 |
| 45 | 4.4 | Interfant-06 | M | 6.6 (10.8) | 4.2993 | 8.0016 | 10.2528 | 8.4346 |
| 46 | 9.1 | Interfant-06 | F | 39.7 (45.2) | 3.1663 | 7.7915 | 9.3985 | 8.2159 |
| 47 | 0.5 | Interfant-06 | F | 8.7 (13.3) | 6.2701 | 6.5276 | 9.9358 | 7.8396 |
| 48 | 6.1 | AIEOP-BFM ALL 2017 | F | 6.6 | 12.6734 | 4.2609 | 9.4741 | 4.7534 |
| 49 | 6.1 | AIEOP-BFM ALL 2017 | F | 8.3 | 4.5847 | 8.1496 | 10.5529 | 7.6922 |
| 50 | 10.6 | / | M | / | 5.0774 | 9.4705 | 5.1199 | 5.4875 |
All samples were taken from PB at the day of diagnosis. Gene expression values are indicated as the ΔCT mean of three technical replicates. F = female, M = male.