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. 2022 Jun 21;12:922554. doi: 10.3389/fcimb.2022.922554

Figure 2.

Figure 2

Microbial composition based on 16S rRNA gene sequencing. (A) Relative abundance of the cervical microbiota at the phylum level. (B) Relative abundance of the cervical microbiota at the genus level. (C) LEfSe cladogram by 16S rRNA gene sequencing of the cervical microbiota in the two groups. Microbial composition was compared at different species levels, from the phylum in the outermost ring to family in the innermost ring. (D) Distribution histogram of LDA score assessed for species with biomarker significance between the HR-HPV infected and uninfected women (P<0.05; LDA score >4). (E) The importance of species at the genus level in the predictive random forest model using the mean decreasing accuracy. (F) ROC curve generated by random forest model predicting five genera in the cervical microbiota. The plots shown in the ROC represent the corresponding optimal threshold.