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. 2022 Jun 21;16:868556. doi: 10.3389/fnins.2022.868556

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Copyright © 2022 Shenouda, Xiao, MacNair, Lau and Robertson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subcellular localization of TDP43-FL and TDP43C-spl in non-neuronal cells. 1321N1 cells (astrocytoma cell line) and BV-2 cells (microglial cell line) were transfected with EGFP-tagged TDP43-FL (A–F) or EGFP-tagged TDP43C-spl (G–L). The EGFP-tagged TDP43-FL (A,D) and blue DAPI- nuclear stain (B,E) were co-localized, both in 1321N1 cells [arrows in (C)] and BV2 cells [arrow in (F)]. EGFP-tagged TDP43C-spl (G,J) and DAPI-staining (H,K) were also co-localized to the nucleus in 1321N1 cells [arrow in (I)] and BV2 cells [arrows in (L)]. Note that TDP43-FL appears diffusely within nuclei, whereas TDP43C-spl forms speckles [indicated by arrows in (I,L)]. Scale bars = 15 μm.