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. 2022 Jun 21;16:868556. doi: 10.3389/fnins.2022.868556

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Copyright © 2022 Shenouda, Xiao, MacNair, Lau and Robertson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subcellular localization of TDP43-FL and TDP43C-spl in neuronal cells. SHSY5Y (human neuroblastoma) and N2a (mouse neuroblastoma) cells were transfected with EGFP-tagged TDP43-FL (A–F) or EGFP-tagged TDP43C-spl (G–L). The EGFP-tagged TDP43-FL (A,D) and blue DAPI nuclear stain (B,E) showed co-localization to the nucleus in both SHSY5Y cells (C) and N2a cells (F). EGFP-tagged TDP43C-spl was localized to the cytoplasm in both SHSY5Y cells (G) and N2a cells (J), with no co-localization with DAPI [(H,K), with overlays shown in (I,L)]. Cytoplasmic localization of aggregate TDP43C-spl is shown by arrows in (I,L). Scale bars = 15 μm.