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. 2022 Jun 21;16:868556. doi: 10.3389/fnins.2022.868556

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Copyright © 2022 Shenouda, Xiao, MacNair, Lau and Robertson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TDP43C-spl aggregates do not recruit TDP43-FL. N2a cells were co-transfected with mRFP-tagged TDP43-FL (A) and EGFP-tagged TDP43C-spl (B). Cells were counterstained with DAPI (C). The merged image (D) shows that the localization of full length TDP-43 is confined to the nucleus [red in (A,D)], whereas TDP43C-spl formed cytoplasmic aggregates [green in (B,D)], that were devoid of full-length TDP-43. Scale bars = 30 μm.