Figure 1: Guideline-directed Medical Therapy Prescription Rates in Heart Failure Registries and Trials.

Percentage of patients prescribed GDMT in large heart failure registries (CHAMP-HF, US-PINNACLE and ESC-HF-LT) and clinical trials (EMPEROR-REDUCED and DAPA-HF).[17,18,23,25,26] SGLT2Is were not recommended for heart failure during these registries and were the study intervention in the EMPEROR-REDUCED and DAPA-HF clinical trials.[17,18] ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin-receptor blocker; ARNI = angiotensin receptor–neprilysin inhibitor; BB = β-blocker; GDMT = guideline-directed medical therapy; MRA = mineralocorticoid receptor antagonist; SGLT2Is = sodium–glucose cotransporter 2 inhibitors.