Figure 4.

A. Whole-genome sequencing of DNA obtained from our case of feline osteogenesis imperfecta (OI) with a 2-bp deletion on exon 3 of CREB3L1. All contigs except vector ends show a 2-bp deletion, which suggests that the mutation is homozygous. B, C. Sanger sequencing of RT-PCR products from the patient and a control cat. B. cDNA sequence of a part of the CREB3L1 exon 3 amplified from the cat with OI showing deletion TG (shaded) compared with that from a control cat. C. cDNA sequence of the control cat. TGTG is shaded.