Figure 2.

FOXF2 positively regulates ALDH⁺and/or CD44^high/CD24^lowpopulations and tumor-initiating capacity in luminal breast cancer cells but negatively regulates those in BLBC cells.A and B, cell populations of ALDH⁺ (A) and CD44^high/CD24^low (B) were assessed by FCM analysis. ∗, p < 0.05 compared with control cells. C, the tumor-initiating capability of the indicated cells was assessed by an in vivo limiting dilution tumor formation assay. Table showing the incidences of xenograft tumors formed by inoculating gradient concentrations of the indicated cells in NOD/SCID mice or nude mice. BLBC, basal-like breast cancers; FCM, flow cytometric.