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. 2022 Jun 26;10(18):5984–6000. doi: 10.12998/wjcc.v10.i18.5984

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Construction of the protein–protein interaction networks of turquoise module genes and the selected hub genes. A: Network of all turquoise module genes excluding the low connectivity genes; B: The cytohubba algorithm used to identify the top 100 hub genes located in the core area of the turquoise module; C: Venn diagram showing an overlap between the protein–protein interaction hub and gene signature/module membership-key genes in the turquoise module. A total of 41 real hub genes finally selected for further analyses.