Figure 14.
(A) Schematic illustration of semiconducting polymer nano-immunomodulator for NIR-induced photodynamic immunotherapy of cancer; (B) In vivo immune responses after NIR photodynamic immunotherapy. (B1) Representative flow cytometric plots and quantitative analysis of mature DCs (CD80+CD86+) in primary tumors and draining lymph nodes at day 3 after photoirradiation. (B2) Representative flow cytometric plots and quantitative analysis of central memory T cells (CD44+CD62L+) among CD4+ T cell subsets and CD8+ T cell subsets in primary tumors at day 24 after photoirradiation. (B3) Immunofluorescence staining images and quantitative analysis of CD8 of primary tumor sections from mice following various treatments. G1, PBS; G2, R837; G3, SPNC (-); G4, SPNI (-); G5, SPNC (+); G6, SPNI (+). Adapted with permission from 86, copyright 2022 John Wiley and Sons.