Figure 15.

(A) Schematic illustration of the therapeutic mechanism of MB@MSP for PDT and immune therapy. (B) Schematic diagram of T cells and EMT-6 tumor cells co-culture system. (C, D) The proliferation rate of T cells was assessed after various treatments by flow cytometry analysis. (E) Quantification of the proliferation rate of T cells. (F) Schematic illustration of the in vitro Transwell co-cultured system, in which EMT- 6 tumor cells were pre-treated and then incubated with T cells. Tumor cells were placed in the upper chamber, and T cells were cultured in the lower chamber. Finally, cytokine secretion by T cells cultured system, measured by ELISA (G). (H) Flow cytometry data for Annexin V-FITC/PI-stained EMT-6 cells with different treatments, the lower left, lower right, upper right, and upper left quadrants represent the viable, early apoptotic, late apoptotic, and dead cells, respectively. Adapted with permission from ⁹⁷, copyright 2021 Elsevier.