Table 3.
Age-stratified risk of cause-specific death in post-pancreatitis diabetes mellitus versus type 2 and type 1 diabetes mellitus
| Mortality | PPDM vs. T2DM |
PPDM vs. T1DM |
||||
|---|---|---|---|---|---|---|
| Crude hazard ratio (95% CI) | Adjusted hazard ratio (95% CI) | p for interaction† | Crude hazard ratio (95% CI) | Adjusted hazard ratio (95% CI) | p for interaction† | |
|
| ||||||
| Vascular | ||||||
| < 45 years | 1.61 (0.36–7.12) | 1.16 (0.19–7.29) | p1 = 0.75 | 1.45 (0.31–6.72) | 0.27 (0.03–2.60) | p1 = 0.19 |
| 45–64 years | 1.05 (0.62–1.79) | 0.85 (0.48–1.49) | p2 = 0.98 | 1.37 (0.76–2.47) | 1.31 (0.68–2.53) | p2 = 0.24 |
| ≥ 65 years | 1.28 (1.04–1.59) | 1.19 (0.96–1.48) | 1.25 (0.96–1.61) | 1.05 (0.80–1.39) | ||
| Cancer | ||||||
| < 45 years | 2.88 (0.95–8.77) | 3.28 (0.82–13.07) | p1 = 0.43 | 3.56 (1.04–12.17) | 7.88 (1.59–39.10) | p1 = 0.14 |
| 45–64 years | 1.99 (1.36–2.90) | 1.83 (1.23–2.73) | p2 = 0.15 | 2.01 (1.31–3.09) | 2.26 (1.42–3.58) | p2 = 0.037 |
| ≥ 65 years | 1.23 (0.96–1.57) | 1.17 (0.92–1.50) | 1.21 (0.90–1.63) | 1.39 (1.02–1.90) | ||
| Non-vascular | non-cancer | |||||
| < 45 years | 2.50 (1.25–5.00) | 1.85 (0.82–4.19) | p1 = 0.41 | 2.53 (1.22–5.24) | 1.81 (0.71–4.62) | p1 = 0.36 |
| 45–64 years | 1.76 (1.30–2.37) | 1.28 (0.92–1.77) | p2 = 0.33 | 1.25 (0.91–1.72) | 1.13 (0.79–1.62) | p2 = 0.082 |
| ≥ 65 years | 1.32 (1.11–1.56) | 1.22 (1.03–1.45) | 0.88 (0.73–1.07) | 0.77 (0.63–0.95) | ||
| All-cause | ||||||
| < 45 years | 2.91 (1.64–5.16) | 2.12 (1.06–4.21) | p1 = 0.16 | 3.26 (1.76–6.07) | 2.86 (1.28–6.36) | p1 = 0.057 |
| 45–64 years | 1.63 (1.27–2.09) | 1.24 (0.95–1.63) | p2 = 0.13 | 1.36 (1.04–1.78) | 1.24 (0.92–1.68) | p2 = 0.013 |
| ≥ 65 years | 1.31 (1.15–1.49) | 1.22 (1.07–1.40) | 1.11 (0.95–1.29) | 1.01 (0.86–1.20) | ||
PPDM post-pancreatitis diabetes mellitus, T2DM type 2 diabetes mellitus, T1DM type 1 diabetes mellitus, 95% CI 95% confidence interval
Adjusted hazard ratios were estimated from multivariable Cox regression models including age, ethnicity, alcohol abuse, ever smoking, social deprivation index, and Charlson comorbidity index as covariates
Significance of difference in adjusted hazard ratios between the < 45 years group and the 45–64 years group (p1) or between the < 45 years group and the ≥ 65 years group (p2), determined using the Altman and Bland method
All p values for interaction were not statistically significant after false discovery rate correction for multiple testing