Table 2.

Clinical features and treatment of bone metastases in NET patients.

	Synchronous		Metachronous		P-value
	n	%	n	%
Bone metastasis site					<0.001
Truncal	28	60	20	80
Limbs	1	2	0	0
Truncal+limbs	15	32	4	16
Unknown	3	6	1	4
Lytic lesions					0.202
Yes	7	15	5	20
No	40	85	20	80
Pain
Yes	20	43	14	56
No	27	57	11	44
Bone complications
Spinal compression	2	4	2	8
Fractures or vertebral collapse	2	4	3	12
Asymptomatic	27	57	10	40
Treatment					0.151
Biphosphonates (only)	6	13	6	24
Radiotherapy (only)	5	10
Biphosphonates and radiotherapy	6	13	3	12
Untreated	30	64	16	64