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Schematic illustrating the key molecules required for thyroid hormone biosynthesis. Mutations in any of these molecules (TSHR, NIS, Pendrin, TG, TPO, DUOX2, DUOXA2, IYD) may cause CH and mutations in the NADPH-oxidase DUOX2 and its accessory protein DUOXA2 are particularly implicated in transient CH. Created with BioRender.com.
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