Search terms for design  1     randomized controlled trial.pt. 2     controlled clinical trial.pt. 3     randomized.ab. 4     placebo.ab. 5     clinical trials as topic.sh. 6     randomly.ab. 7     trial.ti. 8     or/1‐7 9     exp animals/ not humans.sh. 10     8 not 9

Search terms for population  11    Ankle/ or Ankle Joint/ 12     ankle.af. 13     exp Osteoarthritis/ 14     exp Arthritis/ 15     (osteoarthritis or arthritis or arthrosis or osteoarthrosis or (degenerative adj (arthr$ or disease))).af. 16     11 or 12 17     13 or 14 or 15 18     16 and 17

Combining terms  19     10 and 18