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. Author manuscript; available in PMC: 2023 Jun 3.
Published in final edited form as: IEEE/ACM Trans Comput Biol Bioinform. 2022 Jun 3;19(3):1344–1353. doi: 10.1109/TCBB.2021.3120673

TABLE 2:

Top enriched Gene Ontology biological processes terms in gene clusters.

Go term FDR Go term FDR

Cluster 1 (913 genes) Cluster 2 (567 genes)

Oxidative phosphorylation 6.5E-23 G-protein coupled receptor activity 6.8E-10
NIK/NF-kappaB signaling 2.5E-7 Cytokine-cytokine receptor interaction 8.4E-3
Wnt signaling pathway 6.6E-5 Natural killer cell activation involved in immune response 1.4E-3

Cluster 3 (427 genes) Cluster 4 (403 genes)

Focal adhesion 2.6E-16 T cell receptor signaling pathway 2.1E-12
calcium ion binding 3.1E-14 Cell adhesion molecules (CAMs) 2.2E-11
ECM-receptor interaction 4.1E-12 Antigen processing and presentation 8.2E-11
PI3K-Akt signaling pathway 2.9E-10 Jak-STAT signaling pathway 6.5E-3

Cluster 7 (268 genes) Cluster 10 (132 genes)

Cell cycle 1.3E-60 Translational initiation 4.4E-70
cell division 4.1E-40 SRP-dependent cotranslational protein targeting to membrane 5.0E-69
DNA repair 5.9E-9 viral transcription 1.3E-66

Cluster 13 (69 genes) Cluster 27 (17 genes)

Defense response to virus 9.6E-32 Histone core 2.9E-33
Immunity 1.4E-32 Extracellular exosome 6.5E-7

Cluster 29 (12 genes) Cluster 30 (12 genes)

Antigen binding 1.6E-10 Cell adhesion 1.4E-2