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. 2022 Jun 8;25(7):104554. doi: 10.1016/j.isci.2022.104554

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© 2022 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Enrichment of mncfDNA or uscfDNA using pre-library digestions reveal their functional characteristics

Summation of ssDNA enrichment treatments (dsDnase and Heat shock) and dsDNA enrichment (S1, exo 1, and dsLibrary preparation) present different function peak profiles in the mncfDNA and uscfDNA fraction along different elements of a typical gene in samples extracted by (A) QiaM and (B) SPRI.

(C) Compared to the genome ratio (gray dotted line) the proportion of functional peaks varies at different uscfDNA fragment sizes. Different patterns are observed in different extraction methods. Bar graphs represent SE of Mean (SEM). See also Figures S7 and S8.