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. 2022 Jun 21;19(6):1072–1081. doi: 10.7150/ijms.71892

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SKA1 and TRPV2 affected cell migration and invasion in ESCC. (A)(B) QPCR and western blot indicated that SKA1 was significantly inhibited by siETV5 in ECA109 and KYSE150 cells. (C)(D) QPCR and western blot indicated that TRPV2 was significantly inhibited by siETV5 in ECA109 and KYSE150 cells. (E) SKA1 knockdown markedly inhibited migration of ECA109 and KYSE150 cells indicated by migration assay. (F) SKA1 knockdown markedly inhibited invasion of ECA109 and KYSE150 cells indicated by invasion assay. (G) TRPV2 knockdown markedly inhibited migration of ECA109 and KYSE150 cells indicated by migration assay. (H) TRPV2 knockdown markedly inhibited invasion of ECA109 and KYSE150 cells indicated by invasion assay. (I)(J) SKA1 knockdown markedly suppressed migration of ECA109 and KYSE150 cells, as determined via wound healing assay. (K)(L) TRPV2 knockdown markedly suppressed migration of ECA109 and KYSE150 cells, as determined via wound healing assay. *P<0.05; **P<0.01; ***P<0.001.