Fig. 3.
Decorin is significantly increased in CSF of AppNL-F/NL-F mice and a + t− preclinical AD subjects. a Venn diagrams showing the number of proteins with expression levels above one and below one and b significantly changed proteins (p < 0.05) in the CSF of AppNL-F/NL-F mice and NC/MCI/AD human cohorts from abnormal-amyloid/normal-tau subjects. Among those significantly changed proteins, ECM protein decorin is the only significantly upregulated protein in NC subjects and AppNL-F/NL-F mice. c The gene names of significantly upregulated and downregulated proteins in both AppNL-F/NL-F mouse and human CSF. d Venn diagrams showing the number of proteins with expression levels above one and below one and e significantly changed proteins (p < 0.05) in the CSF of AppNL-G-F/NL-G-F mice and NC/MCI/AD human cohorts from abnormal-amyloid/normal-tau subjects. f The gene names of significantly upregulated and downregulated proteins in both AppNL-G-F/NL-G-F mouse and human CSF. # denotes ECM-associated proteins. NC normal cognition, MCI mild cognitive impairment, AD mild to moderate AD-type dementia, CSF cerebrospinal fluid, DCN decorin