Table 1.

Number of proteins with expression level above one or below one in App knock-in mice and in human cohorts

	Abnormal-amyloid/normal-tau						Abnormal-amyloid/abnormal-tau
	and AppNL-F/NL-F			and AppNL-G-F/NL-G-F			and AppNL-F/NL-F			and AppNL-G-F/NL-G-F
	NC	MCI	AD	NC	MCI	AD	NC	MCI	AD	NC	MCI	AD
Number of proteins expression level above one	33	46	35	38	50	37	39	47	53	38	47	53
Number of proteins expression level below one	76	84	81	84	90	86	24	26	27	26	28	29

A detailed list of proteins and comparisons are provided in table S6 and S7