Fig. 1.

Production of ceramide metabolites and their effects on skin wound healing. Illustrated are the four phases of skin wound healing as well as the metabolism of ceramide, by CERK to C1P and by ceramidases to sphingosine. Sphingosine can then be phosphorylated by SphK to S1P, which seems to promote wound healing. C1P, which has been shown to inhibit wound healing, can be dephosphorylated to ceramide by lipid phosphate phosphatase (LPP). C1P inhibits production of 5-HETE and 5-oxo-HETE, which promote wound healing through the OXER receptor. SYR382141 is the novel CERK inhibitor used in the current study by Maus et al. (5). This figure was created with BioRender.com.