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. 2022 Jul 5;22:179. doi: 10.1186/s12906-022-03657-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Cerebral cortex sections from the untreated group showing normal histological features of brain morphology with well-shaped neurons. Cisplatin (CisPT, 12 mg/kg) shot induces severe damage in cerebral cortex regions. Sections of Acacia hydaspica ethyl acetate extract (AHE) pretreated group at 200 mg/kg for 16 days showed significant protection and rescue of neuron damages with slight signs of the CisPT damage tissues. Sections of AHE (400 mg/kg) pretreated for 16 days showed brain regions with fewer damaged tissues than CisPT group and showed near-to normal brain morphology with well-organized nuclei devoid of vacuolation and irregular features