Table 2.
Urine diet biomarker | Non-CKD (n=6) | CKD (n=8) | ||
---|---|---|---|---|
| ||||
Control period | Alkali period | Control period | Alkali period | |
Urea nitrogen, g/d | 9.3 ± 2.0 | 9.5 ± 1.9 | 8.5 ± 1.6 | 8.3 ± 1.8 |
Potassium, mmol/d | 63.0 ± 12.0 | 59.0 ± 12.9 | 52.7 ± 7.1 | 52.5 ± 4.2 |
Sodium, mmol/d | 105.3 ± 21.1 | 94.0 ± 32.8 | 107.7 ± 21.1 | 101.1 ± 10.5 |
Magnesium, mg/d | 84.2 ± 15.5 | 81.5 ± 15.3 | 63.3 ± 22.3 | 61.8 ± 22.1 |
Calcium, mmol/d | 149.7 ± 65.9a | 143.6 ± 80.7b | 53.5 ± 40.7a | 48.9 ± 38.9b |
Sulfate, mmol/d | 34.1 ± 10.6 | 34.3 ± 10.5 | 30.0 ± 10.1 | 30.0 ± 9.3 |
Phosphorus, g/d | 0.6 ± 0.2 | 0.6 ± 0.2 | 0.5 ± 0.1 | 0.5 ± 0.1 |
Data expressed as means ± standard deviations. All participants completed two consecutive 24-hour urine collections at the end of the alkali and control periods except one participant in the non-CKD group who completed one 24-hour urine collection at the end of the control period. Urine electrolytes are calibrated by regression to a constant mean urine creatinine concentration in each individual over the study period. P-values for between group difference during the control and alkali periods were
<0.01 and
0.01, respectively.