Table 1.
Baseline characteristics of patients and outcomes at the 28th day visit.
| Baseline characteristics | All N = 190 | BA.1-infected patients N = 143 (75%) | BA.2-infected patients N = 47 (25%) | p-value |
|---|---|---|---|---|
| Median age (years, Q1-Q3)* | 59 (45–70) | 59 (44–70) | 55 (50–72) | 0.75 |
| ≥ 80 years old (%) | 17 (9) | 14 (10) | 3 (6) | 0.57 |
| Median BMI (Q1-Q3)* | 25 (22–29) | 24 (22–29) | 26 (22–30) | 0.42 |
| Male sex (%)⁎⁎ | 98 (52) | 71 (50) | 27 (57) | 0.38 |
| Immunocompromised patients (%), including: | 136 (72) | 101 (71) | 35 (75) | 0.61 |
| Solid organ transplantation | 55 (40) | 39 (39) | 16 (46) | 0.46 |
| Immunosuppressive therapy including rituximab | 53 (39) | 44 (44) | 9 (26) | 0.06 |
| Ongoing chemotherapy | 29 (21) | 20 (20) | 9 (26) | 0.46 |
| Corticosteroids >10 mg/day for > 2 weeks | 13 (10) | 10 (10) | 3 (9) | 1 |
| Allogeneic hematopoietic stem cell transplantation | 7 (5) | 6 (6) | 1 (3) | 0.68 |
| Systemic lupus or vasculitis with immunosuppressive medications | 7 (5) | 5 (5) | 2 (6) | 1 |
| Cancer | 3 (2) | 1 (1) | 2 (6) | 0.16 |
| Other risk factors for severe COVID-19 (%), including: | 98 (52) | 75 (53%) | 23 (49%) | 0.68 |
| Diabetes (type 1 and type 2) | 30 (31) | 22 (29) | 8 (35) | 0.62 |
| High blood pressure | 28 (29) | 21 (28) | 7 (30) | 0.82 |
| Obesity BMI>30 | 25 (26) | 19 (25) | 6 (26) | 0.94 |
| Other chronic pathologies | 25 (26) | 20 (27) | 5 (22) | 0.64 |
| Chronic kidney disease | 20 (20) | 16 (21) | 4 (17) | 0.78 |
| Congestive heart failure | 7 (7) | 7 (9) | 0 | 0.19 |
| COPD and chronic respiratory failure | 6 (6) | 3 (4) | 3 (13) | 0.14 |
| Having received ≥ 3 doses of vaccine (%)⁎⁎⁎ | 143 (77) | 102 (73) | 41 (89) | 0.08 |
| Positive IgG anti-Spike serology at d0 (%)⁎⁎⁎⁎ | 118 (63) | 85 (61) | 33 (70) | 0.26 |
| Median IgG anti-spike level at d0 (BAU/mL, Q1-Q3) | 531 (120–2383) | 807 (126–2500) | 395 (91–1574) | 0.26 |
| Day 28 outcome (% of patients with available data) | 167/190 (88) | 125/143 (87) | 42/47 (89) | |
| COVID-19–related hospitalization at d28 (%) | 4 (2) | 3 (2) | 1 (2) | 1 |
| COVID-19-related death (%) | 0 | 0 | 0 |
⁎
Age and BMI were missing in 6 BA.1-infected patients and 3 BA.2-infected patients.
⁎⁎
Sex was missing in 1 BA.1-infected patients.
⁎⁎⁎
Vaccination status was missing in 4 BA.1-infected patients and 1 BA.2-infected patients.
⁎⁎⁎⁎
IgG anti-Spike serology was missing in 4 BA.1-infected patients.