Table 6.
Dietary intake of pyridoxine in relation to hip fracture risk among women stratified by body mass index (BMI) and diabetes status, the Singapore Chinese Health Study, 1993–2010
Women with BMI <20 kg/m2 | Women with BMI ≥20 kg/m2 | |||||
---|---|---|---|---|---|---|
Cases | HRa | 95 % CI | Cases | HRa | 95 % CI | |
Pyridoxine (B6) (mg/1,000 kcal/day) | ||||||
Q1 (0.37–0.61) | 65 | 1.0 | 352 | 1.00 | ||
Q2 (0.61–0.69) | 27 | 0.58 | 0.37–0.92 | 258 | 0.86 | 0.73–1.01 |
Q3 (0.69–0.78) | 40 | 0.82 | 0.54–1.24 | 209 | 0.77 | 0.65–0.92 |
Q4 (0.78–1.76) | 32 | 0.77 | 0.49–1.22 | 197 | 0.78 | 0.65–0.93 |
p for trend | 0.37 | 0.002 | ||||
Women without diabetes | Women with diabetes | |||||
Cases | HRb | 95 % CI | Cases | HRb | 95 % CI | |
Pyridoxine (B6) (mg/1,000 kcal /day) | ||||||
Q1 (0.37–0.61) | 348 | 1.00 | 69 | 1.0 | ||
Q2 (0.61–0.69) | 225 | 0.79 | 0.66–0.93 | 60 | 1.00 | 0.70–1.42 |
Q3 (0.69–0.78) | 183 | 0.73 | 0.61–0.88 | 66 | 1.03 | 0.73–1.46 |
Q4 (0.78–1.76) | 178 | 0.75 | 0.62–0.91 | 51 | 0.91 | 0.62–1.33 |
p for trend | 0.0009 | 0.705 |
CI confidence interval
Hazard ratios (HRs) were adjusted for age at recruitment (in years), year of recruitment (1993–1995, 1995–1998), dialect group (Hokkien, Cantonese), level of education in categories (no formal education, primary school, secondary school or higher), total energy intake (in kilocalories per day), smoking status (never, ex-smokers, current smokers), moderate physical activity (none, 2–3 h weekly, 4+ h weekly), dietary calcium intake (quartiles, in milligrams/1,000 kcal/day), dietary soy isoflavones intake (quartiles, in milligrams/1,000 kcal/day), menopausal status (yes, no), use of hormone replacement therapy at recruitment (yes, no), and history of diabetes mellitus and stroke
HRs were adjusted for the all variables listed above plus body mass index (<20, 20–24, 24–28, ≥28 kg/m2) except history diabetes mellitus