Table 1.
Demographic and clinical data
| All subjects (n = 3872) | Controls (N = 2588) | Patients (N = 1284) | Group difference | |
|---|---|---|---|---|
| Females | 2116 (54.6%) | 1303 (50.3%) | 813 (63.3%) | |
| Males | 1756 (45.4%) | 1285 (49.7%) | 471 (36.7%) | χ2 = 58.2, p < 0.001 |
| Age (years) | 42.5 ± 15.5 | 43.3 ± 15.9 | 40.9 ± 14.6 | t = 4.6, p < 0.001 |
| Age of onset (years) | – | – | 29.4 ± 14.0 | – |
| Total CTQ | 36.3 ± 12.7 | 32.6 ± 8.5 | 43.6 ± 16.1 | p < 0.001a |
| Sexual abuse | 5.5 ± 2.2 (233) | 5.2 ± 1.2 (75) | 6.2 ± 3.3 (158) | p < 0.001a |
| Physical abuse | 6.1 ± 2.5 (297) | 5.6 ± 1.7 (91) | 6.9 ± 3.4 (206) | p < 0.001a |
| Emotional abuse | 7.6 ± 4.0 (770) | 6.5 ± 2.5 (246) | 10.0 ± 5.1 (522) | p < 0.001a |
| Physical neglect | 7.0 ± 2.6 (243) | 6.6 ± 2.2 (86) | 8.0 ± 3.1 (157) | p < 0.001a |
| Emotional neglect | 9.9 ± 4.8 (646) | 8.6 ± 3.8 (202) | 12.5 ± 5.5 (444) | p < 0.001a |
| BDI-IIb | – | 5.2 ± 4.4 | 18.6 ± 12.1 | p < 0.001a |
| HDRSb | – | 2.9 ± 3.1 | 15.6 ± 9.8 | p < 0.001a |
| ICV (in mm3) | (1.53 ± 0.19)×106 | (1.54 ± 0.18)×106 | (1.527 ± 0.2)×106 | t = 2.7, p = 0.007 |
CTQ, Childhood Trauma Questionnaire; ICV, total intracranial volume; BDI#, Beck Depression Inventory; HDRS-17#, Hamilton Depression Rating Scale. Shown are mean values±standard deviation. For CTQ subscales, number of subjects above the cut-off are given in brackets.
a
Mann Whitney U test used.
b
From sites that used these ratings.