Table 1.
Demographic information and prevalence of key PheCode comorbidities
| PMBB (18612) |
AFR | EUR | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TUD + (2769) |
TUD − (5466) |
AUD + (592) |
AUD − (7643) |
OUD + (170) |
OUD − (8065) |
TUD + (3883) |
TUD − (6494) |
AUD + (424) |
AUD − (9953) |
OUD + (95) |
OUD − (10282) |
||
| Sex, n (% male) | 9834 (52.8) |
2355 (45.3) |
1822 (33.3)** |
371 (62.7) |
2706 (35.4)** |
76 (44.7) |
3001 (37.2)* |
2801 (72.1) |
3956 (60.9)** |
354 (83.5) |
6403 (64.3)** |
69 (72.6) |
6688 (65.0) |
| Age, M (SD) | 64.9 (16.7) |
61.83 (14.2) |
54.26 (16.8)** |
60.79 (12.3) |
56.5 (16.6)** |
58.04 (12.5) |
56.78 (16.5) |
73.4 (12.1) |
70.1 (14.7)** |
68.4 (11.5) |
71.5 (14.0)** |
62.2 (13.1) |
71.4 (13.9)** |
| # Encounters, M (SD) | 60.7 (69.9) |
96.7 (85.6) |
66.0 (65.3)** |
103.2 (86.1) |
74.2 (72.8)** |
140.4 (106.4) |
75.0 (72.8)** |
53.9 (68.2) |
44.9 (60.6)** |
72.8 (79.8) |
47.2 (62.7)** |
116.1 (113.9) |
47.7 (62.7)** |
| Circulatory System, n(%) | 15327 (82.4) |
2431 (87.8) |
3668 (67.1)** |
523 (88.3) |
5576 (73.0)** |
154 (90.6) |
5945 (73.7)** |
3701 (95.3) |
5527 (85.1)** |
387 (91.3) |
8841 (88.8) |
93 (97.9) |
9135 (88.8)* |
| Endocrine/Metabolic, n(%) | 13686 (73.5) |
2372 (85.7) |
4036 (73.8)** |
502 (84.8) |
5906 (77.3)** |
154 (90.6) |
6254 (75.9)** |
3076 (79.2) |
4202 (64.7)** |
357 (84.2) |
6921 (69.5)** |
85 (89.5) |
7193 (70.0)** |
| Neoplasms, n(%) | 8832 (47.5) |
1820 (65.7) |
3050 (55.8)** |
389 (65.7) |
4481 (58.6)** |
121 (71.2) |
4749 (58.9)* |
2598 (41.2) |
2364 (36.4)** |
210 (49.5) |
3752 (37.7)** |
50 (52.6) |
3912 (38.0)* |
| Neurological, n(%) | 6827 (36.7) |
1533 (55.4) |
2256 (41.3)** |
350 (59.1) |
3439 (45.0)** |
136 (80.0) |
3653 (45.3)** |
1263 (32.5) |
1775 (27.3)** |
183 (43.2) |
2855 (28.7)** |
70 (73.7) |
2968 (28.9)** |
| Respiratory, n(%) | 9416 (50.6) |
1970 (71.1) |
2844 (52.0)** |
440 (74.3) |
4374 (57.2)** |
135 (79.4) |
4679 (58.0)** |
2060 (53.1) |
2542 (39.1)** |
250 (59.0) |
4352 (43.7)** |
69 (72.6) |
4533 (44.1)** |
| Mental disorder, n(%) | 4784 (25.7) |
1296 (46.8) |
1410 (25.8)** |
347 (58.6) |
2359 (30.9)** |
126 (74.1) |
2580 (32.0)** |
955 (24.6) |
1123 (17.3)** |
179 (42.2) |
1899 (19.1)** |
71 (74.7) |
2007 (19.5)** |
| Mood disorders, n(%) | 2598 (14.0) |
823 (29.7) |
780 (14.3)** |
248 (41.9) |
1355 (17.7)** |
106 (62.4) |
1497 (18.6)** |
484 (12.5) |
511 (7.9)** |
110 (25.9) |
885 (8.9)** |
51 (53.7) |
944 (9.2)** |
*
p<0.05
**
p<0.001; Mood disorders is a subset of Mental disorders; AFR=African ancestry; EUR=European ancestry; PMBB=Penn Medicine Biobank; TUD=Tobacco use disorder; AUD=Alcohol use disorder; OUD=Opioid use disorder.