Table 2.

Association between plasma and CSF levels of sST2 to plasma and CSF pro-inflammatory cytokine levels.

	CM CSF ST2 level			CM plasma ST2 level			SMA plasma ST2 level
	n	beta coefficient [95% CI]	P value	n	beta coefficient [95% CI]	P value	n	beta coefficient [95% CI]	P value
Cytokines in Plasma
IL-6	142	−0.04 [−0.13, 0.05]	0.42	206	0.06 [0.01, 0.10]	0.02	183	0.18 [0.11, 0.25]	<0.001
TNF-α	142	0.01 [−0.12, 0.15]	0.84	206	0.13 [0.05, 0.20]	0.001	183	0.20 [0.09, 0.31]	<0.001
IL-1b	140	0.15 [−0.06, 0.35]	0.16	195	−0.03 [−0.14, 0.08]	0.57	157	−0.03 [−0.15, 0.09]	0.62
Cytokines in CSF
IL-6	153	0.24 [0.14, 0.35]	<0.001	147	0.02 [−0.04, 0.09]	0.49
TNF-α	153	0.30 [0.22, 0.39]	<0.001	147	0.05 [−0.01, 0.11]	0.14
IL-1b	122	0.10 [−0.14, 0.35]	0.40	114	0.09 [−0.10, 0.28]	0.35

All factors are continuous variables and were log transformed (base 10) prior to linear regression analysis. Data presented as beta coefficient and 95% CI. Corrected for multiple comparisons using Bonferroni correction within each type of marker, P<0.013 for cytokines in plasma and CSF.

Abbreviations: CM, cerebral malaria; CSF, cerebrospinal fluid; SMA, severe malarial anemia; CI, confidence interval.