Table 3.
Association between plasma and CSF levels of sST2 to clinical risk factors in children with cerebral malaria (CM) or severe malarial anemia (SMA)
| CM CSF | CM Plasma | SMA Plasma | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n,Na | OR [95% CI] | P value | n,Na | OR [95% CI] | P value | n,Na | OR [95% CI] | P value | |
| Clinical Risk Factorsb | |||||||||
| Lactic acidosis | 46, 145 | 1.32 [0.66, 2.63] | 0.43 | 66, 207 | 3.23 [1.19, 8.77] | 0.02 | 80, 178 | 1.57 [0.63, 3.93] | 0.33 |
| Acute kidney injury | 67, 149 | 1.81 [0.94, 3.50] | 0.08 | 88, 215 | 7.61 [2.73, 21.21] | <0.001 | 44, 187 | 10.50 [2.98, 37.04] | <0.001 |
| Elevated BUN | 65, 153 | 2.38 [1.21, 4.68] | 0.01 | 90, 224 | 43.13 [12.25, 151.87] | <0.001 | 52, 193 | 63.66 [13.95, 290.64] | <0.001 |
| Thrombocytopenia | 133, 153 | 2.73 [1.06, 7.08] | 0.04 | 190, 219 | 7.77 [2.08, 29.05] | 0.002 | 100, 192 | 3.52 [1.42, 8.71] | 0.007 |
Associations among levels of sST2 in children with severe malaria with clinical risk factors and clinical lab tests. Plasma and CSF levels of sST2 were log transformed (base 10). Odds ratios (OR) and 95% confidence intervals (CI) are presented. Corrected for multiple comparisons using Bonferroni correction, P<0.013.
Definitions: lactic acidosis, lactate >5 nmol/L, uremia, plasma urea nitrogen >20 mg/dL; thrombocytopenia, platelet count <150,000.
n,N denotes the number of children included in the analysis that were positive for each clinical risk factor compared to the total number of children included in the analysis.
Clinical risk factors are binary outcomes and were analyzed using logistic regression models.
Abbreviations: CM, cerebral malaria; CSF, cerebrospinal fluid; SMA, severe malarial anemia; OR, odds ratio; CI, confidence interval; BUN, blood urea nitrogen.