Table 2.
Odds of different cardiovascular diseases based on polygenic risk score.
| Cardiovascular disease | Odds ratio (95% CI)a | p-value |
|---|---|---|
| Peripheral artery disease | 1.44 (1.41, 1.46) | 1.81 × 10−113 |
| Coronary artery disease | 1.33 (1.32, 1.34) | 9.10 × 10−300 |
| Congestive heart failure | 1.34 (1.33, 1.36) | 7.10 × 10−140 |
| Cerebrovascular disease | 1.20 (1.19, 1.22) | 2.85 × 10−51 |
a
Polygenic risk scores (PRSs) scaled (center PRS −0.07 ± 0.83). Thus, for each 0.83 increase in PRS, the odds of peripheral artery disease or coronary artery disease increase by 44% and 33%, respectively. Odds ratios derived from logistic regression models of each disease, adjusting for age, sex, and first five principal components and using scaled PRS.