Table 1.
Representative FAD-linked mutations in APP gene used in model mice.
| Name | Mutation | Effect on Aβ | Model mouse |
|---|---|---|---|
| Swedish | KM670/671NL | Increased total Aβ; unchanged Aβ42/Aβ40 ratio | Tg2576, APP23, J20, TgCRND8, APPswe/PSEN1dE9, 5xFAD, A7, NL-G-F |
| Arctic | E693G | Arctic Aβ40 forms protofibrils at an increased propensity and faster rate | NL-G-F |
| Dutch | E693Q | Dutch Aβ increases aggregation rates and fibril formation | - |
| Austrian | T714I | Increased Aβ42/Aβ40 | A7 |
| Florida | I716V | Increased Aβ42(43)/Aβ40 | 5xFAD |
| Iberian | I716F | Increased Aβ42/Aβ40 ratio | NL-G-F |
| Indiana | V717F | Increased Aβ42/Aβ40 | PDAPP. J20. TgCRND8 |
| London | V717I | Increased Aβ42/Aβ40 | 5xFAD |