Table 3.
Representative APP model mice.
| Model mouse | Gene (Mutation) | Promoter | Aβ pathology | Tau pathology | Neuronal loss | Cognitive impairment |
|---|---|---|---|---|---|---|
| PDAPP | APP (V717F) | PDGF-β promoter | + (6 mo~) | - | - | + (3 mo~) |
| Tg2576 | APP (KM670/671NL) | hamster prion promoter | + (11 mo~) | - | - | + (6 mo~) |
| APP23 | APP (KM670/671NL) | Thy1 promoter | + (6 mo~) | - | + (12 mo~) | + (3 mo~) |
| J20 | APP (KM670/671NL, V717F) | PDGF-β promoter | + (8 mo~) | - | + (3 mo~) | + (4 mo~) |
| TgCRND8 | APP (KM670/671NL, V717F) | hamster prion promoter | + (3 mo~) | - | + (6 mo~) | + (3 mo~) |
| PS2APP | APP (KM670/671NL) PSEN2 (N141I) | APP: Thy1.2 promoter PSEN2: mouse prion promoter | + (9 mo~) | - | unknown | + (8 mo~) |
| APPswe/PSEN1dE9 (APP/PS1) | APP (KM670/671NL) PSEN1 (delta9) | mouse prion promoter | + (6 mo~) | - | + (8 mo~) | + (12 mo~) |
| Tg-ArcSwe | APP (KM670/671NL, E693G) | Thy1 promoter | + (5 mo~) | - | - | + (4 mo~) |
| 5xFAD | APP (KM670/671NL, I716V, V717I) PSEN1 (M146L, L286V) | Thy1 promoter | + (2 mo~) | - | + (6 mo~) | + (4 mo~) |
| A7 | APP (KM670/671NL, T714I) | Thy1.2 promoter | + (9 mo~) | unknown | unknown | unknown |
| NL-G-F | humanized Aβ sequence (KM670/671NL, I716F, E693G) | Endogenous promoter (knock-in model) | + (2 mo~) | - | - | + (6 mo~) |