Table 5.
Representative tau model mice.
| Model mouse | Gene (Mutation) | Promoter | Aβ pathology | Tau pathology | Neuronal loss | Cognitive impairment |
|---|---|---|---|---|---|---|
| JNPL3 | MAPT 0N4R (P301L) | mouse prion promoter | - | +(5 mo~) | +(5 mo~) | unknown |
| PS19 | MAPT 1N4R (P301S) | mouse prion promoter | - | +(6 mo~) | +(9 mo~) | +(6 mo~) |
| rTg4510 | MAPT 0N4R (P301L) | CaMKII promoter | - | +(4 mo~) | +(6 mo~) | +(6 mo~) |
| 3xTg | APP (KM670/671NL) MAPT 0N4R (P301L) Psen1 (M146V knock-in) | Thy1.2 promoter | +(6 mo~) | +(12 mo~) | unknown | +(4 mo~) |
| MAPT knock-in | MAPT gene | Endogenous promoter (knock-in model) | - | - | - | - |
| NL-G-F/MAPT double knock-in | humanized Aβ sequence (KM670/671NL, I716F, E693G) MAPT gene | Endogenous promoter (knock-in model) | + | - | - | unknown |