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. 2022 Jul 3;14(1):2089006. doi: 10.1080/19490976.2022.2089006

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Bt modulated GLP1 and FGF15 expression. (a) Serum levels of FGF15 and ileal expression of FGF15, IBABP, Ost-α and Ost-β fold over Pair fed vehicle group and determined by qPCR (Pair fed groups = n4-6; EtOH groups = n6-10). (b) Serum levels of GLP-1 and colonic expression of GLP-1, TGR5, GPR43 and PYY fold over Pair fed vehicle group and determined by qPCR (Pair fed groups = n4-6; EtOH groups = n6-10). Data are expressed in mean ± SEM; *p < .05; **p < .01; ***p < .001, according to one-Way ANOVA followed by post hoc analysis (Bonferroni test).

Abbreviations: FGF15, fibroblast growth factor 15; IBABP, ileal bile acid-binding protein; Ost-α/β, Organic solute transporter α/β; GLP-1, Glucagon-like peptide-1; G protein-coupled bile acid receptor 1; GPR43, G-protein-coupled receptor 43; Peptide YY; Bt, Bacteroides thetaiotaomicron.